For more than two decades, Perricone MD Perricone MD has been a holistic, three-tier skincare and wellness system. This consists of diet, essential dietary supplements and potent topical skincare solutions backed by powerful ingredients, cutting-edge research and extensive clinical and consumer studies. Perricone MD was created by Dr. Nicholas Perricone, world-renowned author of New York Times bestseller, The Wrinkle Cure. Dr. Perricone’s seminal work challenged the prevailing norms of the skincare industry with its visionary approach to aging and introduction to the advantages of a healthy lifestyle.